In the Simpsons episode, AABF19 “E-I-E-I-(Annoyed Grunt)” from season 11, episode 5, Homer Simpson accidentally creates the tomacco when he “planted a little bit of everything” and fertilized his tomato and tobacco fields with plutonium. The result is a tomato that apparently has a dried, gray tobacco center, and, although many characters describe it as tasting terrible (Ralph Wiggum: “Eww, Daddy, this tastes like Grandma!” Clancy Wiggum: “Holy Moses, it DOES taste like Grandma!”), it is also immediately and powerfully addictive. Homer promptly labels the creation “Tomacco” and sells it in large quantities to unsuspecting passers by. Laramie cigarettes, seeing an opportunity to sell their products to children legally, offers to buy the rights to market tomacco for $150 million. Homer refuses, demanding $150 billion instead and the company’s executives reject the offer. The hybrid plant is so powerfully addictive that farm animals develop the abilities of speech and bipedal locomotion in their frenzied quest to gain more tomacco. A cow kicks through the wall of the Simpson farmhouse and screams a rudimentary “TOMACCO!” when looking for more. Eventually, the farm animals eat all but one of the tomacco plants. The company executives manage to steal the last tomacco plant as they depart, but a tomacco-crazed sheep attacks them, causing their helicopter to crash, destroying the last remaining plant.

Simpsons Tomacco